Speakers - CARWC2025

Abstract

The skin is a self-renewing organ called an immunological organ where the epidermis can function as a primary lymphoid organ, forming part of our immune system.” There are an estimated 20 billion T cells in human skin, suggesting that immune defense in the skin's dermis can prevent the skin from prematurely breaking down. Additionally, the skin is an independent steroidogenic organ, which means skin can produce cortisol, influence whole-body states, and emotions.        

Stress can disrupt cortisol levels within the body's systems and organs, including the skin. A fact unrecognized by the general public is that anxiety, hormonal imbalances, and gut inflammation can impair the integrity and protective function of the epidermal barrier (our skin). Why is this important? The skin barrier structure and function are crucial for human health, while toxic environments negatively impact skin ecosystems and overall health.

The skin is a neuroendocrine organ, which means there is crosstalk between the skin, the brain, the endocrine, and the immune system. There are multiple neuro-immuno-endocrine functions, including tryptophan hydroxylase, that occur within the skin. Because the skin protects us from injury and environmental toxins, its health depends on its communication with our gut microbiome, skin microbiome, skin immunity, and, surprisingly enough, our bmin.

Toxic products alter the conditions of the skin barrier and contribute to the variation of skin microbiota and oxidative stress. These include poor choices of makeup, cleansers, moisturizers, and antibacterial hand gels. The layers of the epidermis and dermis work in concert to execute immune responses in the skin, while disruptions and imbalances can result in skin disorders and/or infections.

The Department of Dermatology in Sweden studied melanocytes that produce serotonin. Paradoxically, the skin can produce serotonin and convert it into melatonin. As humans, a balance in these neurotransmitters can improve cognitive function, metabolic function, and gastrointestinal function.